Preheat your oven to 450°F. Line a baking sheet with parchment paper.
In a large bowl, whisk together the flour, baking powder, salt, and baking soda. Add the cold butter and mix until the mixture resembles coarse crumbs.
Stir in the buttermilk until just combined. Do not overmix.
Turn the dough out onto a floured surface and gently knead it a few times until it comes together. Pat it into a 1-inch thick rectangle.
Cut out biscuits using a round cutter and place them on the prepared baking sheet. Bake for 12-15 minutes or until golden brown.
While the biscuits are baking, heat about 1 inch of vegetable oil in a large skillet over medium-high heat.
Season the chicken thighs with garlic powder, paprika, black pepper, and cayenne pepper. Fry the chicken in batches for about 5-7 minutes on each side, or until cooked through and golden brown. Drain on paper towels.
In a small bowl, mix together the honey and hot sauce. Drizzle the hot honey over the fried chicken.
To assemble, split the biscuits in half, place a piece of fried chicken on the bottom half, and drizzle with more hot honey. Top with the other half of the biscuit.