Cook the penne pasta according to package instructions until al dente. Drain and set aside.
In a large skillet, heat the olive oil over medium heat. Add the chicken pieces and season with garlic powder, onion powder, salt, and pepper. Cook until the chicken is no longer pink, about 5-7 minutes.
Add the broccoli florets to the skillet and cook for an additional 3-4 minutes until they are tender but still bright green.
Reduce the heat to low and pour in the heavy cream. Stir in the Parmesan cheese and Italian seasoning, mixing until the cheese is melted and the sauce is creamy.
Add the cooked penne pasta to the skillet and toss everything together until the pasta is well coated with the sauce. Cook for an additional 2-3 minutes to heat through.
Serve hot, garnished with fresh parsley.