Jump to Recipe Print RecipeEvery home cook has those evenings when time seems to slip through their fingers like grains of sand. On nights like these, I crave a cozy dish that brings everyone together without a lot of fuss—and that’s when my High-Protein Spinach and Artichoke Chicken Casserole comes to the rescue. This recipe combines tender, shredded chicken with vibrant spinach and artichokes in a creamy sauce, topped with a golden layer of melted cheese. It’s a smart solution for low-carb comfort food that fills you up without weighing you down. Not only does it come together quickly, but it also makes cleanup a breeze, allowing you to kick back and relax while it bakes to perfection. Curious about how to create this deliciously satisfying casserole that’s sure to impress? Let’s dive into the details! Why is this casserole a winning dish? Simplicity at Its Core: This High-Protein Spinach and Artichoke Chicken Casserole comes together effortlessly, leaving you more time to unwind after a busy day. Nutrient-Packed Delight: With wholesome ingredients like spinach and artichokes, it’s a nutritious choice that satisfies! Guilt-Free Indulgence: High in protein yet low in carbs, this dish offers comfort without the heaviness. Versatile and Adaptable: Feel free to swap in your favorite veggies or use leftover rotisserie chicken for convenience—this recipe accommodates every cook’s style! Crowd-Pleasing Comfort: Perfect for family dinners or casual gatherings, this casserole is sure to impress your guests. Elevate your weeknight meals with this dish and consider pairing it with a light green salad for a balanced experience. Check out similar favorites like Caribbean Chicken Rice for more delicious options! High-Protein Spinach and Artichoke Chicken Casserole Ingredients • Get ready to create a dish that’s both nutritious and delicious! For the Casserole Chicken Breasts – This high-protein base provides heartiness; shredded chicken blends perfectly with other flavors. Fresh Baby Spinach – Adds vibrant color and nutrients; feel free to substitute with kale if desired! Artichoke Hearts – Elevate the dish with their tangy profile; canned works beautifully when chopped. Non-Fat Greek Yogurt – This creamy binder packs protein without excess fat; regular yogurt or sour cream can add richness. Light Cream Cheese – Keeps the casserole creamy; stick to light options to maintain a healthier dish. Shredded Mozzarella Cheese – Provides that gooey, melty crust; cheddar is a great alternative if you’re in the mood for something different. Grated Parmesan Cheese – A savory addition that enhances flavors; while optional, it’s highly recommended! Garlic – Infuses the casserole with warmth; fresh minced garlic gives the best punch of flavor. Salt and Pepper – Essential seasonings that elevate the overall taste; season according to your preference. For Serving (Optional) Crusty Bread – Perfect for scooping up the casserole and adding crunch. Light Green Salad – This balances the richness of the dish and adds freshness, making it a great complement. Enjoy crafting this delightful High-Protein Spinach and Artichoke Chicken Casserole that’s bound to be a hit with everyone at the table! Step‑by‑Step Instructions for High-Protein Spinach and Artichoke Chicken Casserole Step 1: Preheat the Oven Begin by preheating your oven to 375°F (190°C). While the oven warms up, grab a medium-sized casserole dish and generously coat it with nonstick spray to prevent any sticking later on. This preparation ensures that your High-Protein Spinach and Artichoke Chicken Casserole will bake evenly and come out easily once it’s done. Step 2: Mix the Sauce In a large mixing bowl, combine the non-fat Greek yogurt, light cream cheese, minced garlic, salt, and pepper. Mix these ingredients until smooth and creamy, creating a delightful base for your casserole. You want this mixture to be well-blended, so take your time, and once it’s ready, it will bring a luscious texture to the final dish. Step 3: Combine the Ingredients Next, gently fold in the shredded chicken, fresh baby spinach, and chopped artichoke hearts into your creamy mixture. Also, add half of the shredded mozzarella cheese to the bowl. Mix until everything is evenly combined, ensuring the chicken and veggies are well-coated with the sauce. This blend is the heart of your High-Protein Spinach and Artichoke Chicken Casserole, so aim for an even distribution. Step 4: Transfer to the Casserole Dish Pour the delicious mixture into the prepared casserole dish, spreading it out evenly. This helps it bake uniformly, allowing each bite to be as flavorful as the last. Be careful not to overfill the dish, as it needs space for rising and bubbling in the oven. Step 5: Add the Cheese Topping Sprinkle the remaining shredded mozzarella and the grated Parmesan cheese on top of the casserole mixture. This cheesy layer will create a beautiful, golden crust and keep everything inside nice and creamy. You want a good amount of cheese coverage for that irresistible gooeyness that will melt into perfection as it bakes. Step 6: Bake to Perfection Slide the casserole into the preheated oven and bake for 30-35 minutes. Keep an eye on it as it cooks; you’re looking for a bubbly, golden-brown top that’s lightly crisped. The aroma filling your kitchen will be a delightful indicator that your High-Protein Spinach and Artichoke Chicken Casserole is on its way to being ready. Step 7: Let it Cool Once baked, remove the casserole from the oven and allow it to rest for about 5 minutes. This step is crucial as it enables the layers to set slightly, making your casserole easier to serve. Patience pays off, especially when unveiling this comforting dish that’s wonderful to share around the table. Expert Tips for High-Protein Spinach and Artichoke Chicken Casserole Use Fresh Ingredients: Opt for fresh baby spinach and high-quality chicken breast for better flavor and nutrition in your High-Protein Spinach and Artichoke Chicken Casserole. Mix Thoroughly: Ensure the sauce and chicken mixture is well-combined. This helps every bite carry that delicious, creamy flavor and prevents uneven cooking. Don’t Overbake: Keep a close eye on your casserole in the oven. Overbaking can lead to tough cheese—remove it when it’s bubbly and golden for perfect texture. Adjust Seasonings: Taste your mixture before baking. Depending on the saltiness of your cheese and yogurt, you might want to adjust salt and pepper for enhanced taste. Rest Before Serving: Giving the casserole 5 minutes to cool after baking makes it easier to serve, creating perfect portions and balanced layers of flavor. What to Serve with High-Protein Spinach and Artichoke Chicken Casserole Create a delightful dining experience that perfectly complements this warm, cheesy casserole. Creamy Garlic Mashed Potatoes: These luscious potatoes are the ultimate comfort food, providing a soft and buttery contrast to the casserole’s textures. Garlic Breadsticks: Crispy on the outside, soft inside, these breadsticks are ideal for soaking up any leftover creamy sauce from your casserole. Crisp Green Salad: A vibrant mix of arugula, cucumber, and cherry tomatoes adds freshness, cutting through the richness of the casserole for a balanced meal. Roasted Asparagus: Lightly seasoned and roasted until tender, asparagus adds a nutty flavor and a charming crunch that enhances the dish’s overall appeal. Sautéed Zucchini Ribbons: A quick sauté brings out the subtle sweetness of zucchini, giving a lighter option that still rounds out the meal beautifully. Chilled White Wine: A glass of chilled Sauvignon Blanc or Pinot Grigio pairs beautifully, with crisp notes that refresh the palate after each creamy bite. Decadent Chocolate Mousse: For dessert, a light chocolate mousse offers a sweet finale to your meal without overwhelming your senses. Make Ahead Options These High-Protein Spinach and Artichoke Chicken Casserole preparations are perfect for busy home cooks looking to save time during hectic weeknights! You can fully prepare the casserole up to 24 hours in advance by assembling all the ingredients and storing the uncooked casserole in the refrigerator (make sure to cover it tightly with foil or plastic wrap to maintain freshness). For an even quicker option, consider mixing all your filling ingredients aside and keeping them in the fridge a day ahead. When you’re ready to serve, simply remove it from the fridge and bake as directed, adding a few extra minutes to ensure it’s heated through. This way, your casserole will still be just as delicious and comforting, providing a nourishing meal with minimal effort! High-Protein Spinach and Artichoke Chicken Casserole Variations Feel free to elevate your casserole game with these delightful twists that add flavor and fun! Kale Swap: Replace spinach with kale for a heartier texture and a vibrant color contrast. Colorful Veggies: Add bell peppers or mushrooms for extra crunch and a burst of flavor in each bite. Rotisserie Rescue: Save time by using shredded rotisserie chicken instead of cooking it from scratch—convenience never tasted so good! Creamy Dream: For a richer dish, swap the non-fat Greek yogurt for full-fat yogurt or sour cream. Cheesy Upgrade: Experiment with different cheeses, like pepper jack or gouda, for a unique flavor profile that excites your palate. Spice it Up: Add a pinch of red pepper flakes or diced jalapeños to kick up the heat and awaken your taste buds. Nutty Crunch: Top with toasted almonds or walnuts just before serving to add a satisfying crunch and nutty flavor. Herb Garden: Infuse your casserole with fresh herbs like thyme or basil for a fragrant twist that enhances the overall experience. Take your time exploring these adaptations, and don’t hesitate to think outside the box! For more delicious meal ideas, try out my Savory Chicken Flatbread or Sweet Chili Chicken! How to Store and Freeze High-Protein Spinach and Artichoke Chicken Casserole Fridge: Store leftover casserole in a tight-lidded container for up to 3 days. This keeps it fresh while preserving the creamy texture and flavors. Freezer: For longer storage, freeze the casserole in an airtight container for up to 3 months. Just make sure to let it cool completely before sealing. Reheating: When ready to enjoy, thaw overnight in the fridge. Reheat in the oven at 350°F (175°C) for about 20-25 minutes until heated through. Microwave is also an option for quicker reheating. Serving Reminder: Always let the casserole rest for 5 minutes after baking, perfect for taste and easier serving, so everyone loves your High-Protein Spinach and Artichoke Chicken Casserole! High-Protein Spinach and Artichoke Chicken Casserole Recipe FAQs What kind of spinach should I use? Absolutely! Fresh baby spinach is my go-to for this recipe as it adds vibrant color and nutrition. If you prefer, you can substitute it with kale, but keep in mind that the flavor and texture may vary slightly. How should I store the leftovers? To keep your casserole fresh, store it in a tight-lidded container in the refrigerator for up to 3 days. This will help maintain its creamy texture and flavors. When you’re ready to enjoy, just reheat it in the microwave or oven. Can I freeze the High-Protein Spinach and Artichoke Chicken Casserole? Yes, you can! To freeze, allow the casserole to cool completely, then transfer it to an airtight container. It can be stored in the freezer for up to 3 months. When you’re ready to enjoy, let it thaw overnight in the fridge and then reheat it in the oven at 350°F (175°C) for about 20-25 minutes until heated through. What should I do if the cheese is tough after baking? To prevent the cheese from becoming tough, avoid overbaking the casserole. Keep an eye on it during the last few minutes of baking, looking for a bubbly, golden-brown top. If it appears to be browning too quickly, covering it loosely with foil can help protect it. Are there any dietary considerations for pets or allergies? While this casserole is delicious for humans, it’s important to note that it contains ingredients such as garlic, which can be harmful to pets. Additionally, if anyone has dairy allergies, consider using dairy-free yogurt and cheese alternatives to accommodate their dietary needs. Always double-check your ingredients for any potential allergens! High-Protein Spinach and Artichoke Chicken Casserole Bliss A delicious High-Protein Spinach and Artichoke Chicken Casserole recipe that combines tender chicken, vibrant spinach, and artichokes in a creamy sauce. Print Recipe Pin Recipe Prep Time 10 minutes minsCook Time 35 minutes minsCooling Time 5 minutes minsTotal Time 50 minutes mins Servings: 4 servingsCourse: CasserolesCuisine: AmericanCalories: 350 Ingredients Equipment Method Nutrition Notes Ingredients 1x2x3x? For the Casserole2 cups Shredded Chicken Breast Use shredded rotisserie chicken for convenience.2 cups Fresh Baby Spinach Substitute with kale if desired.1 cup Chopped Artichoke Hearts Canned works beautifully.1 cup Non-Fat Greek Yogurt Can substitute with regular yogurt.1 package Light Cream Cheese1 cup Shredded Mozzarella Cheese Cheddar can be used as an alternative.1/4 cup Grated Parmesan Cheese Optional, but recommended.2 cloves Minced Garlic Use fresh for best flavor.to taste Saltto taste PepperFor Serving (Optional)1 loaf Crusty Bread Perfect for scooping.1 bowl Light Green Salad Balances the casserole. Equipment Casserole Dish Method Step-by-Step InstructionsPreheat your oven to 375°F (190°C) and coat a medium-sized casserole dish with nonstick spray.In a large bowl, mix Greek yogurt, cream cheese, garlic, salt, and pepper until smooth.Fold in chicken, spinach, artichokes, and half of the mozzarella until evenly combined.Pour the mixture into the prepared casserole dish evenly.Top with remaining mozzarella and Parmesan cheese.Bake for 30-35 minutes until bubbly and golden brown.Let it cool for 5 minutes before serving. Nutrition Serving: 1servingCalories: 350kcalCarbohydrates: 10gProtein: 40gFat: 15gSaturated Fat: 6gPolyunsaturated Fat: 1gMonounsaturated Fat: 8gCholesterol: 90mgSodium: 600mgPotassium: 800mgFiber: 3gSugar: 2gVitamin A: 2500IUVitamin C: 30mgCalcium: 300mgIron: 2mg NotesUse fresh ingredients for better flavor and nutrition. Adjust seasonings to enhance taste. Allow casserole to rest before serving for easier portions. Tried this recipe?Let us know how it was!
